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WHO suspends study on malaria drug for Covid-19

Tuesday May 26 2020

 

By NMG

The World Health Organisation (WHO) has temporarily suspended trials of hydroxychloroquine from its global study into experimental Covid-19 treatments, saying that its experts need to review all available evidence to date.

The UN health agency in March launched a multinational trial on a variety of repurposed drugs to kick-start the search for a treatment for Covid-19.

But on Monday, WHO said the suspension was informed by safety concerns for Covid-19 patients. Naturally, hydroxychloroquine is a medication used to prevent and treat malaria in areas where the mosquito-borne disease remains sensitive to chloroquine.

RISKS TO PATIENTS

Speaking on Monday, WHO Director-General Tedros Adhanom Ghebreyesus said that in light of a paper published last week in the Lancet that showed people taking hydroxychloroquine were at a higher risk of death and heart problems, there would be “a temporary pause” on the hydroxychloroquine arm of its global clinical trial.

“The executive group has implemented a temporary pause of the hydroxychloroquine arm within the Solidarity trial while the safety data is reviewed by the data safety monitoring board,” Tedros said during the Monday online briefing.

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He said the concern related only to the use of hydroxychloroquine and chloroquine for Covid-19, adding that the drugs are accepted treatments for people with malaria and auto-immune diseases.

MALARIA TREATMENT

The drug, also referred to as HCQ, is an approved treatment for malaria and autoimmune diseases like rheumatoid arthritis, lupus, and a type of blood disorder that affects the skin known as Porphyria cutanea tarda (PCT).

“The other arms of the trial are continuing,” added Dr Tedros.

The global trial termed Solidarity trial is being carried out in several countries across the world with Kenyan researchers joining their international counterparts in the search for a cure for Covid-19. There are plans for clinical trials for three drugs.

Other treatments in the WHO’s Solidarity trial, including the experimental drug remdesivir and a combination therapy of two HIV drugs – lopinavir and ritonavir – are still being pursued.

ANIMAL STUDIES

The drugs are being studied because they have all shown some evidence of effectiveness against the SARS-CoV 2 virus, which causes Covid-19, either in cells (in vitro) and or animal studies.

Hydroxychloroquine has been touted by US President Donald Trump and others as a possible treatment for the disease caused by the coronavirus.

The US National Institutes of Health is also running a clinical trial to establish whether the drug, administered with the antibiotic azithromycin, can prevent hospital admissions and death from Covid-19.

The WHO previously recommended against using hydroxychloroquine to treat or prevent coronavirus infections, except as part of clinical trials.

Dr Mike Ryan, the head of the WHO emergencies programme, said the decision to suspend trials of hydroxychloroquine had been taken out of “an abundance of caution”



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By AFP

Davos, Switzerland. Easing US-China trade tensions have lessened uncertainty and the world economy may have hit bottom but a sharp slowdown in India is creating a drag worldwide, the International Monetary Fund said Monday.

However, while the risks to the global economy have grown smaller, the Washington-based global lending institution cautioned that outcomes "depend to an important extent on avoiding further escalation" between Washington and Beijing.

In the latest update to its World Economic Outlook, the IMF cut the global growth estimate for 2020 to 3.3 percent, 0.1 percentage point lower than in the prior report released in October.

It lowered the 2021 forecast by 0.2 percentage points, to 3.4 percent.

The sharp drop for India "accounts for the lion's share of the downward revisions," the IMF said.

IMF chief Kristalina Georgieva pointed to India's struggles with declining consumption and investments, budget deficits and delays in making structural reforms.

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"After a synchronized slowdown in 2019, we expect a moderate pick-up in global growth this year and next," Georgieva told a news conference on the eve of the 50th World Economic Forum in Davos, the annual gathering of business and political elites.

"We are already seeing some tentative signs of stabilization but we have not reached a turning point yet," she cautioned.

The IMF said the relationship between China and the United States, the world's dominant economic powers, is still troubled by "unresolved disputes".

"The risk of protracted subpar global growth remains tangible despite tentative signs of stabilizing momentum," the fund warned in its quarterly report.

"Policy missteps at this stage would further enfeeble an already weak global economy."

The charity Oxfam, in an annual report released Monday, warned of growing social inequality and the pressures that is generating.

It said the world's 2,153 billionaires now have more money than the planet's 4.6 billion poorest people.

"The gap between rich and poor can't be resolved without deliberate inequality-busting policies," Oxfam's India head Amitabh Behar said.

 

- US-China trade deal -

US President Donald Trump signed a deal with China last week that eases the escalating trade tensions but leaves in place tariffs on two-thirds of the goods imported from the Asian economic power.

The trade truce led to an upgrade of China's growth forecast to 6.0 percent in 2020, with a slight slowdown to 5.8 percent projected for next year.

But the giant Asian economy has been on a steadily slowing path for some time.

Meanwhile, the IMF trimmed US growth just a tenth to 2.0 percent this year, and to 1.7 percent in 2021.

Since 2018, Washington and Beijing have exchanged tit-for-tat tariffs on hundreds of billions of dollars in two-way trade.

"Trade truce is not the same as trade peace," Georgieva said on Friday.

In its previous analysis, the IMF estimated that trade conflicts and tariffs cut 0.8 percentage points off of global growth.

But two-thirds of that damage was due not to the tariffs but to trade uncertainty created by the conflict, which causes companies to put the brakes on investment.

If tensions flare again, or if Trump's trade dispute with the European Union or confrontation with Iran should worsen, that too could undermine the "nascent bottoming out of global manufacturing and trade, leading global growth to fall short" of forecasts, the report said.

 

- Slowing growth in India -

Receding risks of a hard Brexit have helped stabilize the outlook for Britain and the European Union. And healthy private consumption has helped the still-slow but upgraded growth prospects in Japan.

However, the IMF once again slashed expected GDP growth in India, by 1.2 percentage points this year and 0.9 points in 2021 compared to the October forecasts.

While growth remains relatively robust at 5.8 percent and 6.5 percent for the two years, respectively, it is not enough to continue to reduce poverty in the growing South Asian economy.

India has for years been a major engine of global expansion along with China, while advanced economies have bumped along at far slower rates.

But it had already been downgraded in October due to a bigger-than-expected decline in domestic demand amid growing stress in the financial sector.

Meanwhile, Latin America continues to slow, even as Brazil has stabilized and growth there was upgraded.

Mexico was downgraded, while Chile suffered "a sizable markdown" amid widespread social unrest. (AFP)


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