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Covid-19 vaccine trials in Africa: What’s promising, and what’s not

Friday December 04 2020
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Scientists are working around the clock to develop and test vaccines against SARS-CoV-2, the causative agent of Covid-19. Experts agree that widespread use of safe and effective vaccines will rapidly contain the Covid-19 pandemic, preventing transmission and disease. A key step in the process of any vaccine development is clinical testing, which involves assigning a vaccine or a placebo to human subjects, then evaluating the health effects over a period of time. This testing helps to demonstrate safety in diverse human populations living in different settings, and to determine vaccine efficacy – the ability to prevent infection and disease.

Globally, Covid-19 vaccine trials are being conducted in all continents, representing all diverse human populations in the world. In Africa, Egypt and South Africa are participating in these trials. Many other countries are also preparing to participate.

To date there are 260 Covid-19 vaccine candidates at different stages of development. Sixty of these are undergoing clinical testing (human trials) in different phases. This includes phase III trials – the point at which scientists aim to determine how well a vaccine protects (efficacy) trial participants from infection or severe Covid-19 symptoms.

November 2020 has been a celebratory month. Preliminary phase III data of three different Covid-19 vaccine candidates showed impressively high efficacy ranging from 70% to 95%. All three – Pfizer/BioNTech, Moderna mRNA-1273 and Oxford ChAdOx1-S vaccines – are in the late stage of phase III clinical trials. Pfizer/BioNTech and Oxford ChAdOx1-S are being tested in Africa too. After investigations of an initial safety concern in phase III trial, the Oxford ChAdOx1-S vaccine testing has proceeded well.

The groundbreaking developments offer hope and optimism. But there are still major obstacles ahead, particularly for developing countries. Chief among these are the fact that at least one of the vaccines showing promise needs to be kept at extremely low temperatures prior to use. This will be a difficult ask for most African countries.

In addition, there are concerns about access to the vaccines once manufacturing starts. Among the key concerns is the availability of sufficient vaccine doses to meet the high demand. And then there’s the question of affordability. Resources will be urgently needed to procure and distribute Covid-19 vaccines at a rapid pace.

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A great deal of focus is being placed on the COVAX Facility, a GAVI co-led global risk sharing plan. This is overseeing the pooling of procurement and equitable distribution of eventual Covid-19 vaccines.

There are three vaccines at phase III stage with a similar choice of an antigen – the SARS-CoV-2 spike protein. But they work differently in the way they teach the immune system to protect our bodies from Covid-19.

Pfizer/BioNTech is a mRNA vaccine. Such vaccines work by instructing the human cells to make a small part of the virus surface protein and induce the appropriate type of immune response that is thought to confer protection. In this case, it is an immune response to the SARS-CoV-2 spike protein. This protein plays a key role in enabling coronaviruses to infect human cells and replicate.

In some infected people, Covid-19 disease develops, whereas others remain asymptomatic, without any signs or symptoms of the disease. Preliminary data show no major safety concerns are associated with a two-dose administration of the vaccine. This mRNA-based Covid-19 vaccine induces T-cell and strong neutralising antibody immune responses. Both T-cell and antibody immune responses are thought to be critical in protecting against Covid-19. A similar mRNA vaccine, made by Moderna, has shown comparable results.

Efficacy of 95% has been reported for the Pfizer/BioNTech (mRNA) vaccine, far exceeding the expectations. This type of vaccine can be rapidly manufactured and scaled to capacity to meet the high demand for millions of doses. If licensed, it will be the first mRNA vaccine approved for human use by the regulatory authorities.

Oxford ChAdOx1-S is a non-replicating viral vector vaccine. The viral vector, or backbone, used in this vaccine is based on the chimpanzee adenovirus (ChAd). The choice of this type of vector is to circumvent common pre-existing immunity to human adenoviruses (HAdV) that would blunt the ability of such a vaccine to engage the human immune system.

Already, scientists have experience with clinical testing (safety and immunological profiles) of the ChAd viral vectored vaccines.

The Oxford ChAdOx1-S works by using a replication-deficient adenovirus vector to conveniently deliver the spike protein to immune cells or tissues, thereby inducing the desired immune response against SARS-CoV-2. The vaccine-induced immunity comprises of T-cell and strong neutralising (infection-blocking) antibody immune responses.

Novavax NVX-CoV2373 is a protein subunit vaccine. Subunit vaccines work by presenting a specific antigen that stimulates the immune system to mount a response.

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 Benjamin Kagina is Senior Research Officer, Vaccines For Africa Initiative, Faculty of Health Sciences, University of Cape Town